US Secretary of State John Kerry has warned Iran that talks on its nuclear programme cannot last forever, after a new round failed to make progress.
"This is not an interminable process," he said after arriving in Istanbul, at the start of a 10-day trip to the Middle East, Europe and Asia.
World powers failed to make headway at two days of talks with Iran in Almaty.
Mr Kerry also called on Turkey and Israel to restore good relations without delay.
After Turkey, Mr Kerry is due to visit Israel, the West Bank, the UK, South Korea, China and Japan.
'Painful task'Mr Kerry said President Barack Obama was committed to continuing the diplomatic process with Iran despite what he called the complicating factor of elections there in June.
"Diplomacy is a painful task," the secretary of state said, "and a task for the patient."
No new round of talks was scheduled after the negotiations in Almaty, Kazakhstan, which ended on Saturday.
World powers suspect Iran of pursuing a covert nuclear weapons programme.
Tehran, which insists its intentions are peaceful, is negotiating with the so-called P5+1 group comprising the five permanent members of the UN Security Council - the US, Russia, China, the UK and France - plus Germany.
'Back on track'After recently helping broker a reconciliation between Turkey and Israel, Mr Kerry said: "We would like to see this relationship that is important to stability in the Middle East and critical to the peace process... get back on track in its full measure.''
That, he told reporters in Istanbul, meant promises of "compensation be fulfilled, ambassadors be returned and full relations be embraced".
Mr Kerry met Turkish Foreign Minister Ahmet Davutoglu and was also due to meet Prime Minister Recep Tayyip Erdogan.
America's top diplomat will also encourage Turkey to continue admitting civilians fleeing the conflict in Syria, following reports - denied by Turkey - that some Syrians had recently been deported after unrest at a border camp.
More than 1.2 million people have fled to neighbouring countries since the unrest in Syria began two years ago, according to UN figures.
At least 250,000 are in Turkey.
Both Turkey and the US oppose Syrian President Bashar al-Assad, with Turkey holding that the West should do more to help the Syrian opposition.
Afghan deathsThe start of Mr Kerry's trip was overshadowed by the death of six Americans, along with an Afghan doctor, in two attacks in Afghanistan.
The Americans included a foreign service officer who had acted as Mr Kerry's guide during his recent visit to Kabul.
Anne Smedinghoff, 25, had been delivering books to students in southern Zabul province.
She was the first US diplomat killed in service since last year's attacks in the Libyan city of Benghazi.
Speaking to US consulate workers in Istanbul, Mr Kerry said Ms Smedinghoff's death was a "grim reminder... of how important, but also how risky, carrying the future is".
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